Liver failure is the 12th leading cause of death in the U.S. Our goal is to generate pure populations of human liver cells from embryonic and induced pluripotent stem cells, thereby providing a source of liver cells for transplantation into patients-in-need. We have shown that embryonic stem cell-derived human liver progenitors can engraft the injured mouse liver, regenerate human liver tissue in vivo, and partially improve survival.
A Roadmap for Human Liver Differentiation from Pluripotent Stem Cells
Ang et al., 2018. Cell Reports 22: 2190-2205.
Evaluating the regenerative potential and functionality of human liver cells in mice
Tan et al., 2017. Differentiation 98:25-34.
We are part of the Institute for Stem Cell Biology & Regenerative Medicine at the Stanford University School of Medicine. Our research is supported by the Siebel Stem Cell Institute and the California Institute for Regenerative Medicine.
Address: Lokey Stem Cell Research Building, 265 Campus Drive, Stanford, CA 94305