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Publications

Research Articles

Pek NMQ, Liu KJ, Nichane M, Ang LT* (2020). Controversies Surrounding the Origin of Hepatocytes in Adult
Livers and the in Vitro Generation or Propagation of Hepatocytes.
Cellular and Molecular Gastroenterology & Hepatology (*corresponding author).

Ang LT*, Tan AKY, Autio MI, Goh SH, Choo SH, Lee KL, Tan JM, Pan B, Lee JH, Lum JJ, Lim YY, Yeo KX, Wong JY, Liu M, Oh LL, Chia PL, Loh CH, Chen A, Chen QF, Weissman, IL, Loh KM, Lim B* (2018). A Roadmap for Human Liver Differentiation from Pluripotent Stem Cells. Cell Reports 22: 2190-2205 (*corresponding authors).

Nichane M, Javed A, Sivakamasundari V, Ganesan M, Ang LT, Kraus P, Lufkin T, Loh KM, Lim B (2017). Isolation and expansion of Sox9+ mouse embryonic lung progenitors that generate both airway and alveolar lineages. Nature Methods 14: 1205-1212.

Koh PW, Sinha R, Barkal AA, Morganti RM, Chen A, Weissman IL*, Ang LT*, Kundaje A*, Loh KM* (2016). An atlas of transcriptional, chromatin accessibility, and surface marker changes in human mesoderm development. Scientific Data 3:160109 (*co-senior authors).

Loh KM, Chen A, Koh PW, Deng T, Sinha R, Tsai JM, Barkal AA, Shen KY, Jain R, Morganti RM, Ng SC, Morganti RM, Fernhoff NB, George BM, Wernig G, Salomon RAE, Chen Z, Vogel H, Epstein JA, Kundaje A, Talbot WS, Beachy PA, Ang LT*, Weissman IL* (2016). Mapping the pairwise choices and leading from pluripotency to human bone, heart and other mesoderm cell-types. Cell 166: 451-467 (*co-senior and co-corresponding authors).

Loh KM*, Ang LT*, Zhang J, Kumar V, Ang J, Auyeong JQ, Lee KL, Choo SH, Lim CYY, Nichane M, Tan J, Noghabi MS, Azzola L, Ng ES, Durruthy-Durruthy J, Sebastiano V, Poellinger L, Elefanty AG, Stanley EG, Chen Q, Prabhakar S, Weissman IL, Lim B (2014). Efficient endoderm induction from human pluripotent stem cells by logically directing signals controlling lineage bifurcations. Cell Stem Cell 14: 237-52 (*co-first and co-corresponding authors).

Teo AK, Arnold SJ, Trotter MW, Brown S, Ang LT, Chng Z, Robertson EJ, Dunn NR, Vallier L (2011). Pluripotency factors regulate definitive endoderm specification through eomesodermin. Genes & Development 25: 238-50.

Lee KL, Lim SK, Orlov YL, Yit LY, Yang H, Ang LT, Poellinger L, Lim B (2011). Graded Nodal/Activin signaling titrates conversion of quantitative phospho-Smad2 levels into qualitative embryonic stem cell fate decisions. PLoS Genetics 7: e1002130.

Sahoo S, Ang LT, Goh JC, Toh SL (2010). Growth factor delivery through electrospun nanofibers in scaffolds for tissue engineering applications. J Biomed Mater Res A 93: 1539-50.

Sahoo S, Ang LT, Goh JC, Toh SL (2010). Bioactive nanofibers for fibroblastic differentiation of mesenchymal precursor cells for ligament/tendon tissue engineering applications. Differentiation 79(2):102-10.

Review Articles and Book Chapters

Tan AKY, Loh KM & Ang LT* (2017). Evaluating the repopulation potential and functionality of human liver cells in mice. Differentiation, 98:25-34 (*corresponding author).

Loh KM, Lim B*, Ang LT* (2015). Ex uno plures: molecular designs for embryonic pluripotency. Physiological Reviews 95 (1) 245-95 (*corresponding authors).

Ang LT, Loh KM & Lim B (2014). Stem cell genomics: developmental competence and lineage commitment. In Principles and Practice of Genomic Medicine (2nd edition), Oxford University Press, NY.